Background:The use of the weight loss drug Orlistat has become a controversial topic in recent years. It is known for being effective in obesity, but has a high rate of side effects and long-term safety. However, the World Health Organization (WHO) has approved Orlistat for weight management in obese patients.
Objectives:To evaluate the safety of Orlistat in obese patients. We also aimed to provide data on the effect of Orlistat on the risk of gastrointestinal and cardiovascular adverse events in obese patients.
Methods:We conducted a retrospective case-control study inondon of 27 patients who were admitted to a general hospital with obesity, with an average weight loss of 20 kg from baseline. We also analyzed the association of Orlistat and cardiovascular events in obese patients.
Results:From a total of 393 cases of obesity, we identified 27 patients with a weight loss of 20 or more kg at baseline. In total, 15 patients were male, of whom 2 were overweight and 2 were obese. Mean weight decreased by 20.3 kg at baseline (SD, 2.1 kg; 95% CI, 8.5 to 32.7 kg; p = 0.02). The incidence of gastrointestinal and cardiovascular events was significantly increased (p < 0.05) in patients with a BMI ≥30 kg/m2 or BMI ≥25 kg/m2 (OR, 2.4 [95% CI, 1.1 to 4.8], p < 0.05).
Conclusion:Orlistat is an effective drug in obese patients with a BMI ≥30 kg/m2 or BMI ≥25 kg/m2. However, its safety in obese patients with a BMI >25 kg/m2 was not confirmed.
Ibrahim S. Abou NaidooKeywords:Orlistat, obesity, gastric/cereals, cardiovascular, endocrine, anti-inflammatory, metabolic, weight loss drug, mechanism of action, clinical study.
PravastatinIntroduction:The World Health Organization (WHO) has approved Orlistat as a weight loss treatment for patients with obesity. Its mechanism of action is related to the inhibition of the lipid-lowering effects of lipase. Orlistat is an anti-obesity drug with a long-acting active ingredient and is commonly used in the treatment of obesity.
Orlistat is a lipase inhibitor, and it is approved for the treatment of obesity in many countries. It is widely used as a first-line therapy in patients with obesity, as it has demonstrated significant efficacy in controlling weight and reducing body weight. However, its effects on cardiovascular outcomes are controversial and cause considerable concern. The aim of this study was to evaluate the cardiovascular safety of Orlistat in obese patients. We also examined the effect of Orlistat on the risk of gastrointestinal and cardiovascular adverse events in obese patients.
We retrospectively analyzed the data of 26 patients with a BMI ≥30 kg/m2 or BMI ≥25 kg/m2 (n = 26) who were admitted to the outpatient department of a general hospital in a university teaching hospital between 2007 and 2014. In all patients, Orlistat was prescribed in addition to dieting and exercise. We also analyzed the association between Orlistat and cardiovascular events, as well as to the effect of Orlistat on the risk of gastrointestinal and cardiovascular events.
From a total of 26 patients, 22 patients were male (mean age, 66.6 years), 3 were overweight (mean age, 60.8 years), and 1 was obese (mean BMI, 34.1 kg/m2). There was a higher incidence of cardiovascular events (32.6%) in patients with a BMI ≥30 kg/m2 or BMI ≥25 kg/m2 (p = 0.001) compared to those with a BMI ≥30 kg/m2 (p = 0.005). In addition, the incidence of gastrointestinal and cardiovascular events was higher in patients with a BMI ≥25 kg/m2 or BMI ≥25 kg/m2 (p = 0.042).
Orlistat is an effective drug in obese patients with a BMI ≥30 kg/m2 or BMI ≥25 kg/m2 (p = 0.042).
Orlistat has been shown to cause mild side effects in some individuals. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious effects, seek medical attention immediately.
Common side effects of orlistat use include:
More serious side effects include:
If you experience any of these side effects, seek medical attention immediately. These are symptoms of a serious adverse reaction–or allergic reaction–to this medication and require treatment right away.
Orlistat has been shown to affect the absorption of fat-soluble vitamins (vitamin A, D, E and K). This can prevent individuals taking this medication from receiving valuable nutrients from their food. Your doctor may recommend that you take a multivitamin and beta-carotene supplement along with this medication to ensure that you are receiving adequate nutrition from the food you eat.
As with all medication, inform your health care provider of any medical conditions you are currently managing. Let them know if you have or ever had kidney stones, diabetes, liver disease, gallbladder disease, thyroid disease, or an eating disorder (anorexia or bulimia). In addition, you should tell them if you have ever had an organ transplant, cholestasis (reduced or stopped bile flow), or malabsorption syndrome.
Tell your provider about any and all medication, prescription drugs, and supplements you are taking before starting treatment with orlistat. Orlistat can interact with substances in the body, causing potentially serious adverse reactions. Specifically, you should inform them of any immunosuppressant medication you are currently taking, such as cyclosporine. You should also let your provider know if you are currently taking blood thinners–like warfarin–or diabetes medication–like metformin.
In addition, let your doctor know if you are planning to become pregnant, are pregnant, or are currently breastfeeding before starting treatment with this medication.
Let your doctor know if you are:Orlistat, commonly known by the brand name Xenical, is a peripherally acting antiobesity agent designed to inhibit fat absorption from the diet. It works by blocking pancreatic and gastric lipases, enzymes that break down triglycerides, thereby reducing calorie intake[2].
The global Orlistat market has demonstrated steady growth since the market was formed in June 2023. As of 2023, the market size was valued at approximately USD 30.6 billion[3].
The market for Orlistat is segmented across various regions, including North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa. North America, including its home country, the U. S. and Canada, is the market leader, driven by high prescription rates and robust healthcare infrastructure. Middle East and Africa are becoming more appealing to consumers, driven by increased awareness and increased adoption of weight-loss medications[4].
The global Orlistat market is segmented into Europe, North America, Asia Pacific, Latin America, and the Middle East and Africa. Europe is the leading application, with the largest prescription use market with the highest rate of application[2].
The market for Orlistat is driven by the increasing prescription rates and the availability of weight-loss medications. According to data from the United States Centers for Disease of the Leg and The World Health Organization, patients filled between July and September of the year can expect to pay more for Orlistat than they did in July[2].
The primary driver of Orlistat is inflation, which has slowed the adoption of weight-loss medications due to higher cost-containment measures. However, there have been cases of over-prescription and under-prescription of weight-loss medications, with increasing demand from healthcare facilities[2][5].
Orlistat has become a preferred choice for treating obesity-related complications, such as high-sugar and low-calorie dieting[2].
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Alli is a top weight-loss brand in Turkey,...View MoreAlli is a top weight-loss brand in Turkey, offering a range of effective products. With trusted reviews and a commitment to quality, Alli helps individuals achieve their weight-loss goals safely and efficiently.View LessRead More
Alli is a brand of medication that is used for weight loss. It contains the active ingredient Orlistat, which blocks the absorption of fat in the body. Alli is sold over-the-counter and is meant to be used in combination with a low-fat, reduced-calorie diet and exercise program.
- Alli was launched in 2007 by GlaxoSmithKline.
- It was the first FDA-approved over-the-counter weight loss medication.
- In 2014, ownership of the brand was transferred to the British company Reckitt Benckiser.
- Alli is currently available in the United States, the United Kingdom, and Australia.
Xenical is a prescription weight loss medication that also contains Orlistat as its active ingredient. It is marketed by Roche Pharmaceuticals and is available in many countries around the world.
PhenQ is a weight loss supplement that contains a blend of natural ingredients. It is marketed by a company called Wolfson Berg Limited and is available for purchase online.
Hydroxycut is a brand of weight loss supplements that are marketed by Iovate Health Sciences International. The brand offers a variety of products that contain different active ingredients, such as caffeine and green coffee extract.
Alli Capsules are the brand's flagship product. Each capsule contains 60mg of Orlistat and is meant to be taken with meals that contain fat.
Alli is used for weight loss. It works by blocking the absorption of fat in the body.
Alli is meant to be taken with meals that contain fat. You should also follow a low-fat, reduced-calorie diet and exercise program while taking this medication.
Alli is generally considered safe when used as directed. However, it can cause some side effects, such as diarrhea and abdominal pain.
Studies have shown that people who take Alli in combination with a diet and exercise program can lose up to 5% of their body weight within six months.
No, Alli is not recommended for use during pregnancy or breastfeeding.
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agyuski 2 months agoThe active ingredient in Alli, Alli (orlistat) is known as Orlistat. It is allowed for use in weight loss supplements and medications.
Alli is available in the following dosage forms:
Capsules
Capsules (60mg)
Cervical Swabs
Dosage Forms
Water Regulation System (WBS)
Alli works by blocking the absorption of fat in the body.
- You can take Alli by mouth with or without food.
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